KPMG has taken 52,000 sq ft of office space at 66 Queen Square in Bristol.
Skanska has prelet the first to third floors on a 15-year lease.
66 Queen Square is a 61,000 sq ft Grade A office building in Bristol City centre. The property will complete in the summer of 2015.
There is 9,000 sq ft now available to let on the ground and fourth floors.
KPMG was advised by JLL.
JLL and Alder King are the letting agents at 66 Queen Square.