Stanhope is to take 14,000 sq ft of office space at 80-110 New Oxford Street.
They will occupy the second floor of the property on a ten-year lease.
Other tenants in the building include: Space Ape Games, who took 14,300 sq ft of office space on the first floor.
6,000 sq ft on the sixth floor is currently under offer.
Cushman & Wakefield acted for Stanhope plc.
Tishman Speyer was advised by Edward Charles & Partners and Bluebook.