Crest Nicholson will take space at Building 2 at Abbey View in St Albans.
The Housebuilding has signed for 7,818 sq ft in which base its new Chiltern division.
The Chiltern division will serve the Northern Home Counties region.
Building 2 is developed by Threadneedle. Rental rates in the building are in the region of £25 sq ft.
Crest Nicholson was advised by DTRE.
Threadneedle was advised by knight Frank and Stimpsons.